Study: Smoking causes long-lasting DNA damage

Study: Smoking causes long-lasting DNA damage

We are searching data for your request:

Forums and discussions:
Manuals and reference books:
Data from registers:
Wait the end of the search in all databases.
Upon completion, a link will appear to access the found materials.

Smoking can cause disease-causing genetic effects
Smoking is bad for our health is widely known. But not only does our health suffer, our DNA also seems to be damaged. Researchers have now found that smoking actually affects our DNA. Some of these damages regenerate over time, but unfortunately not others.

Hebrew SeniorLife and Harvard Medical School researchers found that smoking can damage DNA. Most of the disease-causing genetic effects disappear after about five years of abstinence from smoking. However, some of the changes never seem to regenerate. The doctors published the results of their study in the journal "Circulation: Cardiovascular Genetics".

The negative effects of smoking last up to 30 years
There are clear patterns that smoking damages human DNA. Some of the damage seems to be irreparable. The study found compelling evidence that smoking has long-lasting effects on our molecular machinery, the researchers emphasize, "These effects can last up to 30 years," explains Dr. Roby Joehanes of Hebrew Seniorlife and Harvard Medical School.

Genetic damage leads to heart disease and cancer
For example, genetic damage can cause heart disease and cancer. Many of the genetic damage is usually inherited. But some also arise from our daily behavior. Smoking seems to be one of the main reasons for the development of genetic damage, the doctors add.

Study examines the data from 16,000 subjects
For their study, the scientists examined the data from 16,000 subjects. They found that the process of DNA methylation in smokers can cause chemical changes in the basic building blocks of a cell's genetic makeup. The majority of the negative effects of DNA methylation appear to have regenerated after five years if people quit smoking. So the body tries to heal the damage of tobacco smoking over time, says Dr. Joehanes.

Subjects had to submit blood samples and fill out questionnaires
The research team examined the blood samples from 16,000 subjects. These samples came from various studies. In all of these examinations, people had to submit blood samples and fill out questionnaires about smoking, diet, lifestyle and general health, the experts explain.

More than 7,000 genes are affected by smoking
The scientists found that the pattern of methylation changes can affect more than 7,000 genes. This corresponds to about a third of the known human genes, the authors explain. Many of the genes were known to be linked to heart disease and cancer.

How long does it take for the body to recover from the damage?
When people quit smoking, most of these negative changes regenerate. For successful regeneration, sufferers no longer have to smoke for about five years, the doctors say. However, some of the changes take longer. Smoking leads to long-term changes in 19 genes, including the so-called TIAM2 gene. The changes take about 30 years to regenerate, the scientists say.

Methylation affects the regulation of gene expression
These results are important because the methylation influences the regulation of gene expression, the scientists explain. When people quit smoking, the effects of smoking on human DNA can be determined years later. Smoking is the most common cause of preventable diseases. Around six million people worldwide die each year from cancer, heart, lung and other diseases, the doctors explain. These health problems are often due to smoking.

Further research needs to determine the mechanisms of the effects
Decades after people quit smoking, there is still a long-term risk of many diseases. These include, for example, some cancers, chronic obstructive pulmonary disease and strokes, the scientists explain. The mechanisms for these long-term effects are unfortunately still relatively unclear.

Quit Smoking!
The results make it clear that it is important to quit smoking. However, many smokers have problems with it. You suffer from withdrawal symptoms or simply do not have the will to do so. Perhaps these people could be helped to reduce their addiction by smoking cigarette placebos. Another study recently showed that these placebo cigarettes can reduce nicotine cravings. But British scientists also found that e-cigarettes can also help you quit. (as)

Author and source information

Video: How Coronavirus Kills: Acute Respiratory Distress Syndrome ARDS u0026 COVID-19 Treatment (July 2022).


  1. Bredon

    as you would read carefully, but you have not understood

  2. Taran

    I believe you were wrong. I'm sure. I propose to discuss it.

  3. Atl

    I think you will allow the mistake. Write to me in PM, we'll talk.

  4. Sebert

    The question is removed

  5. Deasach

    In my opinion, mistakes are made. I am able to prove it. Write to me in PM, it talks to you.

  6. Richard

    I think you have written very well, this experience will be useful to many, and this topic was described not but without such a detailed presentation

  7. JoJogor

    Strange as that

Write a message