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Ibuprofen increases the risk of cardiovascular disease if you have osteoarthritis or rheumatoid arthritis
The risk of cardiovascular disease increases far higher with the use of the painkiller ibuprofen than with other pain medicines if the patients suffer from arthrosis or rheumatoid arthritis. This was the result of a recent study that was presented at the congress of the European Cardiology Society in Barcelona. Ibuprofen is often used in practice to relieve pain and inflammation.
Nonsteroidal anti-inflammatories such as ibuprofen and naproxen and the cox-2 inhibitor celecoxib are among the most widely prescribed and used drugs worldwide. Both classes of drugs are known to cause side effects such as increased blood pressure. Even small increases in blood pressure can increase the risk of cardiovascular diseases and the associated mortality. Now, a recent study shows that ibuprofen has a significantly less favorable effect than naproxen and celecoxib.
A total of 444 US patients participated in the study, 408 suffered from osteoarthritis, 36 from rheumatoid arthritis. All patients had coronary artery disease or were at higher risk. A third of the patients received Celecoxib (2x 100-200 mg daily), a third each ibuprofen (3x 600-800 mg daily) or naproxen (2x 375-500 mg daily). After four months, blood pressure was compared to that at the start of the study.
While celecoxib reduced blood pressure by 0.3 mmHg on average, it increased by 3.7 mm with ibuprofen and 1.6 mmHg with naproxen. "The increase in blood pressure among ibuprofen is significant," says Prof. Frank Ruschitzka, head of the study and deputy director of the Clinic for Cardiology at the University Heart Center Zurich. Ibuprofen is "clearly not as safe as previously thought". The results are of great clinical importance, especially for older patients who often suffered from osteoarthritis and high blood pressure, Ruschitzka explains: «Lowering blood pressure by only 2 mmHg reduces the risk of heart attack by ten percent and the mortality risk in coronary heart disease by seven percent . »
The study now carried out is a supplementary study to the PRECISION study. This has already shown that celecoxib did not increase the risk of cardiovascular diseases more than naproxen and ibuprofen. Both naproxen and ibuprofen are available without a prescription and are taken by hundreds of millions of people annually. Both drugs have been shown to cause stomach and intestinal problems, as well as damage to the kidneys and stomach lining.